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The most widely used in the treatment of arterial hypertension, especially in its early stages, when the increased activity of the sympathoadrenal system is strongly expressed, was found by ?-blockers. By blocking ?-adrenergic receptors of the heart, drugs reduce the strength and frequency of heart contractions, reduce venous blood flow to the heart, inhibit renin secretion in the kidneys, lower vascular tone due to autoregulatory mechanisms and, in the aggregate of all effects, lower blood pressure.

They are especially effective in hypertension accompanied by tachycardia, arrhythmias, or angina pectoris. With their use, the frequency of severe complications of hypertension (myocardial infarction and sudden death) decreases.

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