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The analgesic effect is practically not accompanied by respiratory depression, a decrease in the motility of the gastrointestinal tract, and an increase in the tone of the urinary tract.
Compared to morphine, the drug has a slight narcotic potential (less risk of drug dependence), it is not included in the list of drugs. The drug is used for postoperative pain and other pain syndromes (with myocardial infarction, malignant tumors, injuries). Higher doses for adults inside and under the skin: single - 0.001 g, daily - 0.003 g. Indications for use At appointment these drugs No necessary- sti apply salt potassium.
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An increase in the content of sodium chloride in the diet contributes to the acceleration of the excretion of lithium salts from the body.
With a rational dosage, long-term continuous use of lithium preparations is possible.
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Quinidine-like agents reduce the rate of passage of sodium ions through the sodium channels of the cell membrane, slow down conduction through the atria, AV node, His bundle and Purkinje fibers, lengthen the effective refractory period of the atria.
When using drugs, the automatism of the sinus node, ectopic pacemakers is suppressed and the threshold for ventricular myocardial fibrillation increases. Quinidine and propafenone, unlike other drugs in this group, reduce the flow of calcium ions into cardiomyocytes, showing a weak negative inotropic effect.
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