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Pharmachologic effect Biotransformation of drugs is carried out under the influence of enzymes of microorganisms, intestinal walls, blood plasma, various organs and tissues.
Enzymes of the endoplasmic reticulum of liver cells play a leading role in the process.
To study the interaction of drugs, it is very important to know that many of them are able to change the activity of microsomal enzymes. Substances that increase their activity are called inductors. Currently, about a hundred such compounds are known. The most productive and well-studied inducers of microsomal enzymes are phenobarbital, phenytoin, rifampicin, etc. Some drugs can increase the activity of enzymes that catalyze their own chemical transformations (autoinduction). Sometimes enzyme inducers of the endoplasmic reticulum of liver cells are used to accelerate the biotransformation of endogenous compounds (metabolites) or xenobiotics (substances foreign to the body). Thus, phenobarbital and rifampicin, which promote the formation of glucuronides, can be used to treat congenital
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