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They are active against streptococci, less active against staphylococci, highly resistant to the action of ?-lactamases.

Some 3rd generation cephalosporins are active against Pseudomonas aeruginosa (cefoperazone, ceftazidime, ceftriaxone).

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For an effective impact on pathophysiological processes and for the rational use of multivitamin preparations, one should take into account the possible synergism and antagonism in the interactions between vitamins, as well as the long-term consequences of the influence of individual vitamins on biochemical processes in the human body.

With the simultaneous use of vitamins with other drugs, it is necessary to take into account all adverse reactions that may occur.

With the simultaneous use of vitamins with antacids, the absorption of vitamins is impaired. With simultaneous administration with vitamin C, the absorption of oral contraceptives is impaired. With the simultaneous use of nitrates and nitrites with vitamin A, intracranial pressure increases.

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